In the pantheon of luxury sedans, the Mercedes-Benz S-Class stands as an undisputed icon. It’s the benchmark, the car that often introduces technology the rest of the automotive world adopts years later. For discerning buyers seeking the pinnacle of comfort, technology, and engineering, it represents the ultimate choice. But what if you could have all that prestige without the V8 price tag or fuel bill? Among its various iterations, the Mercedes S400 4matic holds a particularly interesting position.
This specific model, often found as a highly desirable used Mercedes S400 4MATIC, offers a unique blend of sophisticated performance, all-weather capability, and the undeniable prestige of a flagship sedan, all powered by a refined V6 engine. This comprehensive Mercedes S400 4MATIC review will delve into what makes this Mercedes S-Class V6 4MATIC such a compelling vehicle, exploring its features, ownership experience, and its standing in today market.
Understanding the Mercedes S400 4MATIC
So, what do all those letters and numbers on the trunk actually mean? Think of it as the car resume. Breaking it down helps us understand exactly what we’re looking at.
The S-Class Pedigree
The “S” in S-Class signifies “Sonderklasse” or “Special Class.” This isn’t just marketing fluff; it’s a mission statement from Mercedes-Benz. Since its official designation in the 1970s, the S-Class has been the brand technological flagship, a rolling showcase of its latest advancements in luxury, safety, and innovation. When you buy an S-Class, you’re buying into a legacy of being the best. The Mercedes S400 4MATIC fully inherits this legacy, offering a suite of premium features that can still feel futuristic today.
The “400” Designation: Power and Efficiency
In the world of Mercedes, the numbers once directly correlated to engine displacement. While that’s become more of a general indicator of power level now, the “400” in this context is significant. For the W222 generation (the model years we’re primarily focused on), this refers to a potent 3.0-liter twin-turbocharged V6 engine. It delivers robust horsepower (around 329 hp) and ample torque, ensuring the smooth, effortless acceleration you expect from a luxury cruiser. It offers a more balanced approach, providing more than enough power for any real-world situation while improving upon the Mercedes S400 4MATIC fuel consumption compared to its larger V8 siblings.
The “4MATIC” Advantage: All-Weather Confidence
This might be the most important part of the name for many drivers. 4MATIC is Mercedes-Benz permanent all-wheel-drive system. Unlike some systems that only engage when slip is detected, 4MATIC is always on, intelligently distributing power between the front and rear wheels. This dramatically enhances traction, stability, and driver confidence, especially in challenging conditions like rain, snow, or on winding roads. It transforms the S-Class from a fair-weather limousine into a highly practical, year-round executive transport.
A Glimpse into History: The S400 Evolution
The “S400” badge didn’t just appear out of nowhere. Its story is one of evolution, reflecting the industry’s shift towards more efficient powertrains.

The W221 S400 Hybrid: A Precursor
Before the model we know and love, the “S400” badge first appeared on the previous W221 generation as the S400 Hybrid. This was one of the first production hybrids to use a lithium-ion battery. It combined a 3.5-liter V6 with a small electric motor, focusing on improving fuel efficiency and providing a smooth start-stop function. However, it’s crucial to distinguish this model—it was typically rear-wheel drive and a different powertrain altogether.
The W222 S400 4MATIC: Coming into its Own
The true Mercedes S400 4MATIC as most enthusiasts know it arrived with the stunning W222 generation, which launched for the 2014 model year. This is the car that solidified the V6 twin-turbo with all-wheel drive as a cornerstone of the S-Class lineup. It offered a more accessible entry point without sacrificing the core S-Class experience, making it a popular choice for those who valued balance and practicality.
The Evolution of 4MATIC Technology
Mercedes-Benz has been refining its 4MATIC system for decades. Early systems were more mechanical, but the version found in the W222 S-Class is a sophisticated electronic marvel. It works seamlessly with the car stability and traction control systems to proactively manage grip, often correcting for a potential loss of traction before the driver even notices.
Under the Hood and Inside the Cabin
Let’s get to the heart of the matter. What’s it like to drive and live with a Mercedes S400 4MATIC?
The Heart of the S400 4MATIC: Engine and Transmission
The 3.0-liter M276 twin-turbo V6 is a gem. It’s exceptionally smooth and quiet, providing a wave of torque that makes city driving and highway cruising feel completely effortless. Paired with Mercedes’ smooth-shifting 7G-TRONIC (or later 9G-TRONIC) automatic transmission, the powertrain is a masterclass in refinement. While it may not have the thunderous roar of a V8, it delivers its power with a quiet confidence that is arguably more in line with the S-Class character.
A Sanctuary on Wheels: Mercedes S400 4MATIC Interior Features
Stepping inside a W222 S-Class is an event. The cabin is a stunning blend of classic luxury and modern technology. The Mercedes S400 4MATIC interior features are a major selling point.

Seating and Ergonomics
The seats are less like car seats and more like exquisite pieces of furniture. Wrapped in supple leather, they are endlessly adjustable, heated, ventilated, and often equipped with sublime massage functions. Finding a perfect driving position is easy, and arriving at your destination feeling more refreshed than when you left is a common occurrence.
Infotainment and Connectivity
The dashboard is dominated by two large 12.3-inch screens, a feature that was revolutionary at its launch and still looks impressive today. One screen serves as the digital instrument cluster, while the other manages the COMAND infotainment system. It controls everything from navigation and media to the car extensive settings, all navigated via a central rotary dial.
Ambient Lighting and Atmosphere
One of the W222 most celebrated features is its customizable ambient lighting. Strips of soft LED light trace the lines of the dashboard and doors, offering a choice of colors to suit your mood. It sounds like a gimmick, but in practice, it creates a wonderfully serene and luxurious atmosphere, especially during night drives.
Exterior Design and Presence
The W222 S-Class is a masterclass in understated elegance. Its design is clean, majestic, and free of unnecessary lines. It has an immense road presence without being ostentatious. The Mercedes S400 4MATIC shares this timeless design, ensuring it looks just as stately and expensive today as it did when it first rolled out of the showroom.
Driving Dynamics: Refinement Meets Capability
The Silken Ride: AIRMATIC Suspension
The legendary S-Class ride quality is delivered by its standard AIRMATIC adaptive air suspension. This system uses air springs and adaptive dampers to iron out road imperfections, resulting in a ride that feels like you’re gliding on a cushion of air. According to automotive reviewers like Edmunds, the W222 ride is often described as “sublime” and “class-leading,” a sentiment widely shared by owners Edmunds, 2015 Review. This is the magic carpet ride that defines the S-Class experience.
Confident Handling with 4MATIC
You might think a large, comfortable sedan would handle like a boat, but the S400 4MATIC is surprisingly composed. The 4MATIC system provides immense grip, allowing you to power out of corners with confidence. While it’s no sports car, its handling is secure, predictable, and always feels stable, regardless of the weather.

Performance and Everyday Driving
In the real world, the V6 engine provides more than enough punch. Acceleration is brisk, and highway merging and overtaking are accomplished with zero drama. It’s a powertrain that never feels strained, perfectly complementing the car relaxed and luxurious demeanor.
The Ownership Experience: What to Expect from a Used S400 4MATIC
This is where things get real. Owning a flagship luxury car is a dream, but what’s the reality, especially for a used Mercedes S400 4MATIC?
S400 4MATIC Reliability: A Closer Look
The W222 generation is generally considered to be well-built. However, it’s a profoundly complex machine. The key to S400 4MATIC reliability is diligent, preventative maintenance. A car with a complete service history from a reputable dealer or specialist is worth its weight in gold.
W222 S400 4MATIC Common Issues
While no car is perfect, some potential issues to be aware of include electronic glitches with the complex COMAND system, potential wear on suspension components, and the occasional sensor failure. Forums like MBWorld.org are filled with owner experiences that can provide valuable insight into what to look for.
S400 4MATIC Air Suspension Problems
The AIRMATIC system that provides that magical ride can also be a source of significant expense if it fails. Leaks in the air springs or a failing compressor are the most common culprits. A pre-purchase inspection should always include a thorough check of the suspension system’s health.
S400 4MATIC Maintenance Cost: Preparing for Ownership
This is not a Toyota Camry. The S400 4MATIC maintenance cost will be higher than a standard car. Oil changes, brakes, and tires are all premium items. Our advice? Budget at least $1,500-$2,500 per year for maintenance and potential repairs. Finding a trusted independent mechanic who specializes in Mercedes-Benz can save you a significant amount compared to dealership prices.

Mercedes S400 4MATIC Fuel Consumption
For a large, heavy, all-wheel-drive sedan, the fuel economy is respectable. You can expect to see figures in the high teens for city driving and mid-to-high 20s on the highway, depending on your driving style. It requires premium fuel, which is an important factor for your running cost calculations.
Mercedes S400 4MATIC Depreciation Rate
Here’s the best news for used buyers. The Mercedes S400 4MATIC depreciation rate is significant. A car that cost over $100,000 new can often be purchased for a third of that price after 5-7 years. This makes it an incredible value proposition, allowing you to experience world-class luxury for the price of a new, well-equipped family sedan.
S400 4MATIC vs. S450 4MATIC Comparison
Later in the W222 life cycle, Mercedes introduced the S450, which eventually replaced the S400. The S400 4MATIC vs S450 4MATIC comparison is a common question for buyers.
The Next Generation: Inline-Six with EQ Boost
The biggest difference is the engine. The S450 uses a new 3.0-liter inline-six engine with a 48-volt mild-hybrid system called EQ Boost. This system provides a small electric boost for better acceleration and allows the engine to shut off while coasting for improved efficiency. As noted by Car and Driver, this inline-six is exceptionally smooth and technologically advanced Car and Driver, 2018 S450 Review.
Performance and Efficiency Differences
The S450 has a bit more horsepower (around 362 hp) and feels slightly more responsive thanks to the EQ Boost system. It’s also marginally more fuel-efficient. However, the real-world difference in feel is subtle, and the S400 twin-turbo V6 is by no means a slouch.
Is Mercedes S400 4MATIC a Good Used Car?
So, after all this, what’s the verdict? Is Mercedes S400 4MATIC a good used car? Absolutely, but with a crucial caveat: it’s for the informed and prepared buyer.

Value Proposition
The value is undeniable. You are getting a flagship luxury experience—unparalleled comfort, advanced technology, and immense prestige—for a fraction of its original price. It’s a phenomenal amount of car for the money.
Who is it For?
This car is perfect for the discerning driver who values comfort and all-weather security over outright sportiness. It’s for someone who wants the S-Class experience, understands that luxury ownership comes with responsibility, and has budgeted accordingly for maintenance.
Key Considerations Before Buying
- Pre-Purchase Inspection (PPI): This is non-negotiable. Have a specialist mechanic thoroughly inspect the car, paying close attention to the air suspension, electronics, and engine.
- Service History: A complete, documented service history is the best indicator of a well-cared-for car.
- Extended Warranty: Consider purchasing a reputable third-party extended warranty for peace of mind against major repair bills.
The Future of S-Class and the S400 Legacy
The Mercedes S400 4MATIC represents a specific point in the S-Class timeline—a bridge between the traditional, large-displacement era and the current era of electrification. Its legacy is carried on by the mild-hybrid S-Class models and the all-electric EQS sedan. Mercedes-Benz continues to push the boundaries with features like its Level 3 autonomous DRIVE PILOT system, showcasing its commitment to innovation Mercedes-Benz Group, 2023. The S400 proved that a more efficient, V6-powered S-Class could be a resounding success without diluting the brand core values.
Conclusion
The Mercedes S400 4MATIC stands as a testament to balanced excellence. It masterfully combines the opulence and technological prowess of the S-Class with the practicality of a more efficient V6 engine and the all-weather confidence of 4MATIC all-wheel drive. For those considering a used Mercedes S400 4MATIC, it presents an almost unbelievable opportunity to own a piece of automotive royalty.
While the potential S400 4MATIC maintenance cost and known W222 S400 4MATIC common issues require careful consideration, its timeless design, serene driving experience, and incredible value proposition make it an undeniably attractive choice. This Mercedes S400 4MATIC review highlights its status as a smart, sophisticated, and deeply luxurious sedan for the discerning buyer who knows exactly what they’re looking for.
Mercedes S400 4matic FAQs
Question: What makes the Mercedes S400 4MATIC a good used car value?
Answer: The Mercedes S400 4MATIC offers immense luxury, advanced technology, and all-wheel-drive capability for a fraction of its original price due to significant depreciation. Its refined V6 engine and comfortable ride provide a premium experience, making it an attractive proposition for buyers seeking high-end features without the new car cost.
Question: What are common reliability concerns for a used Mercedes S400 4MATIC?
Answer: Common concerns for a used Mercedes S400 4MATIC often include potential issues with the complex AIRMATIC air suspension, electronic components of the COMAND infotainment system, and various sensors. Diligent maintenance and a thorough pre-purchase inspection are crucial to mitigate these risks and ensure S400 4MATIC reliability.
Question: How does the S400 4MATIC compare to the S450 4MATIC?
Answer: The S400 4MATIC typically features a 3.0L twin-turbo V6, while the S450 4MATIC (its successor) utilizes a more advanced 3.0L inline-six engine with a 48-volt mild-hybrid EQ Boost system. The S450 generally offers slightly more power and better efficiency due to its integrated electric assist.
Question: What is the typical S400 4MATIC maintenance cost?
Answer: Owning a Mercedes S400 4MATIC involves higher maintenance costs than average cars. Expect to budget $1,500-$2,500 annually for routine servicing, premium parts, and potential repairs. Complex systems like air suspension can incur significant expenses if they require replacement, so a good service history is vital.
Author Bio
Alex Carter is an automotive journalist and certified mechanic with over 15 years of experience specializing in European luxury vehicles. Having owned and serviced numerous Mercedes-Benz models, Alex brings a hands-on, practical perspective to his reviews, focusing on the real-world ownership experience. His work aims to help enthusiasts make informed decisions by blending technical expertise with a passion for automotive excellence.
Disclaimer
This blog post is intended for informational purposes only. The information provided is based on extensive research, industry knowledge, and publicly available data as of the time of writing. While every effort has been made to ensure accuracy, vehicle specifications, market conditions, and potential issues can vary. Always conduct a thorough pre-purchase inspection (PPI) by a qualified mechanic before buying any used vehicle. The author and publisher are not responsible for any decisions made based on the content of this article.
You can refer to more:
- Official Mercedes-Benz S-Class History : Provides authoritative historical context and evolution of the S-Class lineage, reinforcing the prestige of the Mercedes S400 4MATIC.
- Edmunds Used Mercedes-Benz S-Class Reviews & Pricing : Offers in-depth expert reviews, consumer ratings, and current market value estimates for used Mercedes S400 4MATIC models, crucial for potential buyers.
- Car and Driver Mercedes-Benz S-Class Test Drives : Provides professional driving impressions, performance figures, and detailed analysis from a respected automotive publication, enriching the Mercedes S400 4MATIC review.
- Kelley Blue Book Used Car Value : A trusted industry standard for estimating the fair market price of a used Mercedes S400 4MATIC, helping readers understand its depreciation and current worth.




